Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections.
Exp Eye Res
; 219: 109033, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35288107
ABSTRACT
Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor material transfer process is likely to be mediated by nanotube-like structures connecting donor and host photoreceptors. By leveraging cone-specific reporter mice and super-resolution microscopy we provide evidence for the transfer of cytoplasmic material also from endogenous cones to endogenous rod photoreceptors and the existence of nanotube-like cell-cell connections possibly mediating this process in the adult mouse retina, together with preliminary data indicating that horizontal material transfer may also occur in the human retina.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Fotorreceptoras Retinianas Bastonetes
/
Células Fotorreceptoras Retinianas Cones
Limite:
Animals
Idioma:
En
Revista:
Exp Eye Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha