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A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity.
Eslami-Mossallam, Behrouz; Klein, Misha; Smagt, Constantijn V D; Sanden, Koen V D; Jones, Stephen K; Hawkins, John A; Finkelstein, Ilya J; Depken, Martin.
Afiliação
  • Eslami-Mossallam B; Kavli Institute of NanoScience and Department of BionanoScience, Delft University of Technology, Delft, 2629HZ, the Netherlands.
  • Klein M; Dept. Building Physics and Systems, TNO Building and Construction Research, Leeghwaterstraat 44, Delft, The Netherlands.
  • Smagt CVD; Kavli Institute of NanoScience and Department of BionanoScience, Delft University of Technology, Delft, 2629HZ, the Netherlands.
  • Sanden KVD; Department of Physics and Astronomy, and LaserLaB Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, the Netherlands.
  • Jones SK; Kavli Institute of NanoScience and Department of BionanoScience, Delft University of Technology, Delft, 2629HZ, the Netherlands.
  • Hawkins JA; Department of Physics and Astronomy, and LaserLaB Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, the Netherlands.
  • Finkelstein IJ; Kavli Institute of NanoScience and Department of BionanoScience, Delft University of Technology, Delft, 2629HZ, the Netherlands.
  • Depken M; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA.
Nat Commun ; 13(1): 1367, 2022 03 15.
Article em En | MEDLINE | ID: mdl-35292641
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Proteína 9 Associada à CRISPR Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Proteína 9 Associada à CRISPR Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda