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Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors.
Morel, Carole; Montgomery, Sarah E; Li, Long; Durand-de Cuttoli, Romain; Teichman, Emily M; Juarez, Barbara; Tzavaras, Nikos; Ku, Stacy M; Flanigan, Meghan E; Cai, Min; Walsh, Jessica J; Russo, Scott J; Nestler, Eric J; Calipari, Erin S; Friedman, Allyson K; Han, Ming-Hu.
Afiliação
  • Morel C; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. carole.morel@mssm.edu.
  • Montgomery SE; Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. carole.morel@mssm.edu.
  • Li L; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Durand-de Cuttoli R; Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Teichman EM; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Juarez B; Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Tzavaras N; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Ku SM; Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Flanigan ME; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Cai M; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Walsh JJ; Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Russo SJ; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Nestler EJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Calipari ES; Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Friedman AK; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Han MH; Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Seattle, WA, USA.
Nat Commun ; 13(1): 1532, 2022 03 22.
Article em En | MEDLINE | ID: mdl-35318315
Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone and comorbid conditions. Here, utilizing the chronic social defeat stress (CSDS) paradigm that induces singular or combined anxiety- and depressive-like phenotypes in mice, we show that a ventral tegmental area (VTA) dopamine circuit projecting to the basolateral amygdala (BLA) selectively controls anxiety- but not depression-like behaviors. Using circuit-dissecting ex vivo electrophysiology and in vivo fiber photometry approaches, we establish that expression of anxiety-like, but not depressive-like, phenotypes are negatively correlated with VTA → BLA dopamine neuron activity. Further, our optogenetic studies demonstrate a causal link between such neuronal activity and anxiety-like behaviors. Overall, these data establish a functional role for VTA → BLA dopamine neurons in bi-directionally controlling anxiety-related behaviors not only in anxiety-alone, but also in anxiety-depressive comorbid conditions in mice.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexo Nuclear Basolateral da Amígdala Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexo Nuclear Basolateral da Amígdala Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos