Effect of Different Exercise Training Modalities on Fasting Levels of Oxylipins and Endocannabinoids in Middle-Aged Sedentary Adults: A Randomized Controlled Trial.
Int J Sport Nutr Exerc Metab
; 32(4): 275-284, 2022 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-35339112
ABSTRACT
This study aimed to investigate the effects of different exercise training programs on fasting plasma levels of oxylipins, endocannabinoids (eCBs), and eCBs-like molecules in middle-aged sedentary adults. A 12-week randomized controlled trial was conducted using a parallel group design. Sixty-five middle-aged adults (40-65 years old) were randomly assigned to (a) no exercise (control group), (b) concurrent training based on international physical activity recommendations (PAR group), (c) high-intensity interval training (HIIT group), and (d) HIIT together with whole-body electromyostimulation (HIIT + EMS group). Plasma levels of oxylipins, eCBs, and eCBs-like molecules were determined in plasma samples before and after the intervention using targeted lipidomics. Body composition was assessed through dual-energy X-ray absorptiometry, and dietary intake through a food frequency questionnaire and three nonconsecutive 24-hr recalls. The physical activity recommendations, HIIT, and HIIT-EMS groups showed decreased plasma levels of omega-6 and omega-3-derived oxylipins, and eCBs and eCBs-like molecules after 12 weeks (all Δ ≤ -0.12; all p < .05). Importantly, after Bonferroni post hoc corrections, the differences in plasma levels of omega-6 and omega-3 oxylipins were not statistically significant compared with the control group (all p > .05). However, after post hoc corrections, plasma levels of anandamide and oleoylethanolamide were increased in the physical activity recommendations group compared with the control group (anandamide Δ = 0.05 vs. -0.09; oleoylethanolamide Δ = -0.12 vs. 0.013, all p ≤ .049). In conclusion, this study reports that a 12-week exercise training intervention, independent of the modality applied, does not modify fasting plasma levels of omega-6 and omega-3 oxylipins, eCBs, and eCBs-like molecules in middle-aged sedentary adults.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxilipinas
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Treinamento Intervalado de Alta Intensidade
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Int J Sport Nutr Exerc Metab
Assunto da revista:
CIENCIAS DA NUTRICAO
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MEDICINA ESPORTIVA
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METABOLISMO
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Espanha