Disrupted Surfaces of Porous Membranes Reduce Nuclear YAP Localization and Enhance Adipogenesis through Morphological Changes.
ACS Biomater Sci Eng
; 8(5): 1791-1798, 2022 05 09.
Article
em En
| MEDLINE
| ID: mdl-35363465
ABSTRACT
The disrupted surface of porous membranes, commonly used in tissue-chip and cellular coculture systems, is known to weaken cell-substrate interactions. Here, we investigated whether disrupted surfaces of membranes with micron and submicron scale pores affect yes-associated protein (YAP) localization and differentiation of adipose-derived stem cells. We found that these substrates reduce YAP nuclear localization through decreased cell spreading, consistent with reduced cell-substrate interactions, and in turn enhance adipogenesis while decreasing osteogenesis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Adipogenia
Idioma:
En
Revista:
ACS Biomater Sci Eng
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos