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The human vestibulo-ocular reflex and compensatory saccades in schwannoma patients before and after vestibular nerve section.
Pogson, Jacob M; Taylor, Rachael L; Bradshaw, Andrew P; McGarvie, Leigh; D'Souza, Mario; Flanagan, Sean; Kong, Jonathan; Biggs, Nigel; Shivalingam, Brindha; Greenberg, Simon; Croxson, Glen; Halmagyi, G Michael; Welgampola, Miriam S.
Afiliação
  • Pogson JM; Sydney Medical School, The University of Sydney, Sydney, Australia; Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia; Otolaryngology, Head, Neck and Skull Base Surgery Department, St Vincent's Hospital, Sydney, Australia.
  • Taylor RL; Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia; Department of Physiology, University of Auckland, Auckland, New Zealand.
  • Bradshaw AP; Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
  • McGarvie L; School of Psychology, The University of Sydney, Sydney, Australia; Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
  • D'Souza M; Sydney Medical School, The University of Sydney, Sydney, Australia; Clinical Research Centre, Royal Prince Alfred Hospital, Sydney, Australia.
  • Flanagan S; Otolaryngology, Head, Neck and Skull Base Surgery Department, St Vincent's Hospital, Sydney, Australia; Faculty of Medicine, University of New South Wales, Sydney, Australia.
  • Kong J; Neurosurgery Department, Royal Prince Alfred Hospital, Sydney, Australia; Otolaryngology Head and Neck Surgery Department, Royal Prince Alfred Hospital, Sydney, Australia.
  • Biggs N; Otolaryngology, Head, Neck and Skull Base Surgery Department, St Vincent's Hospital, Sydney, Australia.
  • Shivalingam B; Otolaryngology Head and Neck Surgery Department, Royal Prince Alfred Hospital, Sydney, Australia.
  • Greenberg S; Ear Nose and Throat Department, St George Private Hospital, Sydney, Australia.
  • Croxson G; Otolaryngology Head and Neck Surgery Department, Royal Prince Alfred Hospital, Sydney, Australia.
  • Halmagyi GM; Sydney Medical School, The University of Sydney, Sydney, Australia; Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
  • Welgampola MS; Sydney Medical School, The University of Sydney, Sydney, Australia; Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address: miriam@icn.usyd.edu.au.
Clin Neurophysiol ; 138: 197-213, 2022 06.
Article em En | MEDLINE | ID: mdl-35370080
ABSTRACT

OBJECTIVE:

To examine the vestibulo-ocular reflex (VOR) and compensatory-saccades before and after complete unilateral vestibular deafferentation (UVD).

METHODS:

Forty patients were studied before and after surgery for vestibular or facial schwannoma using the video head-impulse test (vHIT) and multivariable regression.

RESULTS:

Prior to UVD (median(IQR), 14(58.4) days), the average VOR-gain towards the lesioned-ear was lower than in normal for all semicircular canals (lateral, anterior, posterior 0.69, 0.72, 0.49). One-week after UVD (5(3.0) days) VOR gains were further reduced (0.22, 0.37, 0.27), however, within one-year after UVD (171(125.0) days) the lesioned-ear VOR gains had slightly increased (+0.08, +0.11, +0.03), maximally for the anterior-canal. After UVD, the VOR gain asymmetry (gain towards minus away from intact-ear) was lower for the intact posterior-canal plane (0.56, 0.56, 0.22). For the lesioned canals, the frequency and amplitude of the first compensatory-saccade increased from 61-93% and 1.9-3.6° pre-surgery, to 98-99% and to 3.1-5.9° one-week post-surgery and remained unchanged over one-year; second saccade frequency and amplitude decreased over the same timespan.

CONCLUSIONS:

After UVD the high-acceleration VOR for the intact posterior-canal plane is more symmetrical than the other canals. First compensatory-saccades adapt within one week and subsequently change only marginally.

SIGNIFICANCE:

Saccade compensation from surgical UVD is near complete by one-week.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reflexo Vestíbulo-Ocular / Neurilemoma Limite: Humans Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reflexo Vestíbulo-Ocular / Neurilemoma Limite: Humans Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália