The Antiepileptic Valproic Acid Ameliorates Charcot-Marie-Tooth 2W (CMT2W) Disease-Associated HARS1 Mutation-Induced Inhibition of Neuronal Cell Morphological Differentiation Through c-Jun N-terminal Kinase.

Memezawa, Shiori; Sato, Takanari; Ochiai, Arisa; Fukawa, Miku; Sawaguchi, Sui; Sango, Kazunori; Miyamoto, Yuki; Yamauchi, Junji

Memezawa, Shiori; Sato, Takanari; Ochiai, Arisa; Fukawa, Miku; Sawaguchi, Sui; Sango, Kazunori; Miyamoto, Yuki; Yamauchi, Junji.

Afiliação

Memezawa S; Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Sato T; Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Ochiai A; Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Fukawa M; Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Sawaguchi S; Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Sango K; Diabetic Neuropathy Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, 156-8506, Japan.
Miyamoto Y; Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Yamauchi J; Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. yamauchi@toyaku.ac.jp.

Neurochem Res ; 47(9): 2684-2702, 2022 Sep.

Article em En | MEDLINE | ID: mdl-35380399

Assuntos

Aminoacil-tRNA Sintetases/metabolismo; Doença de Charcot-Marie-Tooth; Ácido Valproico; Anticonvulsivantes/farmacologia; Anticonvulsivantes/uso terapêutico; Doença de Charcot-Marie-Tooth/tratamento farmacológico; Doença de Charcot-Marie-Tooth/genética; Humanos; Proteínas Quinases JNK Ativadas por Mitógeno; Proteínas Mutantes/genética; Mutação; RNA de Transferência; Ácido Valproico/farmacologia; Ácido Valproico/uso terapêutico

Palavras-chave

Charcot-Marie-Tooth (CMT) disease; Differentiation; Histidyl-tRNA synthetase 1 (HARS1); Mutation; Valproic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Charcot-Marie-Tooth / Ácido Valproico / Aminoacil-tRNA Sintetases Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Neurochem Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

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