Applying Modeling and Simulations for Rational Dose Selection of Novel Toll-Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need.

Klopp-Schulze, Lena; Shaw, Jamie V; Dong, Jennifer Q; Khandelwal, Akash; Vazquez-Mateo, Cristina; Goteti, Kosalaram

Klopp-Schulze, Lena; Shaw, Jamie V; Dong, Jennifer Q; Khandelwal, Akash; Vazquez-Mateo, Cristina; Goteti, Kosalaram.

Afiliação

Klopp-Schulze L; Translational Medicine, the healthcare business of Merck KGaA, Darmstadt, Germany.
Shaw JV; Translational Medicine, EMD Serono, Billerica, Massachusetts, USA.
Dong JQ; Translational Medicine, EMD Serono, Billerica, Massachusetts, USA.
Khandelwal A; Translational Medicine, the healthcare business of Merck KGaA, Darmstadt, Germany.
Vazquez-Mateo C; Translational Medicine, EMD Serono, Billerica, Massachusetts, USA.
Goteti K; Translational Medicine, EMD Serono, Billerica, Massachusetts, USA.

Clin Pharmacol Ther ; 112(2): 297-306, 2022 08.

Article em En | MEDLINE | ID: mdl-35390178

Assuntos

Tratamento Farmacológico da COVID-19; Receptor 7 Toll-Like; Relação Dose-Resposta a Droga; Humanos; Interleucina-6

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 7 Toll-Like / Tratamento Farmacológico da COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

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