Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway.

Parsons, Richard B; Kocinaj, Altin; Ruiz Pulido, Gustavo; Prendergast, Sarah A; Parsons, Anna E; Facey, Paul D; Hirth, Frank

Parsons, Richard B; Kocinaj, Altin; Ruiz Pulido, Gustavo; Prendergast, Sarah A; Parsons, Anna E; Facey, Paul D; Hirth, Frank.

Afiliação

Parsons RB; King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London SE1 9NH, UK.
Kocinaj A; King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London SE1 9NH, UK.
Ruiz Pulido G; King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London SE1 9NH, UK.
Prendergast SA; King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London SE1 9NH, UK.
Parsons AE; King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London SE1 9NH, UK.
Facey PD; Swansea University, Singleton Park Campus, Swansea University Medical School, Swansea SA2 8PP, UK.
Hirth F; King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neurosciences Institute, Department of Basic & Clinical Neuroscience, 5 Cutcombe Road, London SE5 9RX, UK.

Hum Mol Genet ; 31(17): 2918-2933, 2022 08 25.

Article em En | MEDLINE | ID: mdl-35397003

Assuntos

Neuroblastoma; Nicotinamida-Nucleotídeo Adenililtransferase; Doença de Parkinson; Sinucleinopatias; Neurônios Dopaminérgicos/metabolismo; Humanos; NAD/metabolismo; Neuritos/metabolismo; Neuroblastoma/metabolismo; Nicotinamida-Nucleotídeo Adenililtransferase/genética; Nicotinamida-Nucleotídeo Adenililtransferase/metabolismo; Doença de Parkinson/metabolismo; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Sinucleinopatias / Neuroblastoma / Nicotinamida-Nucleotídeo Adenililtransferase Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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