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Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
Grychowska, Katarzyna; Olejarz-Maciej, Agnieszka; Blicharz, Klaudia; Pietrus, Wojciech; Karcz, Tadeusz; Kurczab, Rafal; Koczurkiewicz, Paulina; Doroz-Plonka, Agata; Latacz, Gniewomir; Keeri, Abdul Raheem; Piska, Kamil; Satala, Grzegorz; Pegiel, Joanna; Trybala, Wojciech; Jastrzebska-Wiesek, Magdalena; Bojarski, Andrzej J; Lamaty, Frédéric; Partyka, Anna; Walczak, Maria; Krawczyk, Martyna; Malikowska-Racia, Natalia; Popik, Piotr; Zajdel, Pawel.
Afiliação
  • Grychowska K; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland. Electronic address: katarzyna.grychowska@uj.edu.pl.
  • Olejarz-Maciej A; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Blicharz K; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Pietrus W; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31-324, Kraków, Poland.
  • Karcz T; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Kurczab R; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31-324, Kraków, Poland.
  • Koczurkiewicz P; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Doroz-Plonka A; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Latacz G; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Keeri AR; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Piska K; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Satala G; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31-324, Kraków, Poland.
  • Pegiel J; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Trybala W; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Jastrzebska-Wiesek M; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Bojarski AJ; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31-324, Kraków, Poland.
  • Lamaty F; IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier, France.
  • Partyka A; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Walczak M; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland.
  • Krawczyk M; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31-324, Kraków, Poland.
  • Malikowska-Racia N; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31-324, Kraków, Poland.
  • Popik P; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31-324, Kraków, Poland.
  • Zajdel P; Faculty of Pharmacy Jagiellonian University Medical College, 9 Medyczna Str, 30-688, Kraków, Poland. Electronic address: pawel.zajdel@uj.edu.pl.
Eur J Med Chem ; 236: 114329, 2022 Jun 05.
Article em En | MEDLINE | ID: mdl-35397400
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Inibidores da Monoaminoxidase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Inibidores da Monoaminoxidase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article