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Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity.
Barsi, Szilvia; Papp, Henrietta; Valdeolivas, Alberto; Tóth, Dániel J; Kuczmog, Anett; Madai, Mónika; Hunyady, László; Várnai, Péter; Saez-Rodriguez, Julio; Jakab, Ferenc; Szalai, Bence.
Afiliação
  • Barsi S; Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary.
  • Papp H; National Laboratory of Virology, University of Pécs, Pécs, Hungary.
  • Valdeolivas A; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
  • Tóth DJ; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany.
  • Kuczmog A; Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary.
  • Madai M; National Laboratory of Virology, University of Pécs, Pécs, Hungary.
  • Hunyady L; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
  • Várnai P; National Laboratory of Virology, University of Pécs, Pécs, Hungary.
  • Saez-Rodriguez J; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
  • Jakab F; Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary.
  • Szalai B; MTA-SE Laboratory of Molecular Physiology, Budapest, Hungary.
PLoS Comput Biol ; 18(4): e1010021, 2022 04.
Article em En | MEDLINE | ID: mdl-35404937
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: PLoS Comput Biol Assunto da revista: BIOLOGIA / INFORMATICA MEDICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hungria
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: PLoS Comput Biol Assunto da revista: BIOLOGIA / INFORMATICA MEDICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hungria