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Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.
Patel, Meena V; Peltier, Hillary M; Matulenko, Mark A; Koenig, John R; C Scanio, Marc J; Gum, Rebecca J; El-Kouhen, Odile F; Fricano, Meagan M; Lundgaard, Greta L; Neelands, Torben; Zhang, Xu-Feng; Zhan, Cenchen; Pai, Madhavi; Ghoreishi-Haack, Nayereh; Hudzik, Thomas; Gintant, Gary; Martin, Ruth; McGaraughty, Steve; Xu, Jun; Bow, Daniel; Kalvass, John C; Kym, Philip R; DeGoey, David A; Kort, Michael E.
Afiliação
  • Patel MV; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA. Electronic address: meena.v.patel@abbvie.com.
  • Peltier HM; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Matulenko MA; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Koenig JR; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • C Scanio MJ; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Gum RJ; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • El-Kouhen OF; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Fricano MM; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Lundgaard GL; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Neelands T; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Zhang XF; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Zhan C; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Pai M; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Ghoreishi-Haack N; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Hudzik T; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Gintant G; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Martin R; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • McGaraughty S; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Xu J; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Bow D; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Kalvass JC; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Kym PR; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • DeGoey DA; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Kort ME; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
Bioorg Med Chem ; 63: 116743, 2022 06 01.
Article em En | MEDLINE | ID: mdl-35436748
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Canais de Sódio Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Canais de Sódio Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article