Should body mass index replace age to drive the decision for endometrial sampling in premenopausal women with abnormal uterine bleeding?
Gynecol Endocrinol
; 38(5): 432-437, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-35442132
ABSTRACT
OBJECTIVE:
This study aimed to evaluate risk factors for endometrial intraepithelial neoplasia/malignancy in premenopausal women with abnormal uterine bleeding or oligomenorrhea. Specifically, we aimed to elucidate whether body mass index (BMI) or age confers a higher risk. STUDYDESIGN:
A retrospective cohort study was performed at a large academic center examining risk factors for endometrial hyperplasia/malignancy in premenopausal women undergoing endometrial sampling.RESULTS:
Of the 4170 women ages 18-51 who underwent endometrial sampling from 1987 to 2019, 77 (1.85%) were found to have endometrial intraepithelial neoplasia or malignancy. Clinical predictors of EIN/malignancy in this population included obesity (OR 3.84, 95%, p < .001), Body mass index [(OR30 vs. 252.11, p < .001) and OR35 vs. 30 1.65, p < .001], Diabetes (OR 3.6, p-value <.001), hormonal therapy use (OR 2.93, p < .001), personal history of colon cancer (OR 9.90, p = .003), family history of breast cancer (OR 2.65, p < .001), family history of colon cancer (OR 3.81, p < .001), and family history of endometrial cancer (OR 4.92, p = .033). Age was not significantly associated with an increased risk of disease. Adjusting for other factors, a model using BMI to predict the risk of EIN/malignancy was more discriminative than a model based on age.CONCLUSIONS:
Increased BMI, may be more predictive of endometrial hyperplasia/malignancy than age in premenopausal women with abnormal uterine bleeding. Modification of evaluation guidelines in a contemporary demographic setting could be considered.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Uterinas
/
Neoplasias Uterinas
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Neoplasias do Endométrio
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Neoplasias do Colo
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Hiperplasia Endometrial
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Gynecol Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
/
GINECOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos