IGF-dependent dynamic modulation of a protease cleavage site in the intrinsically disordered linker domain of human IGFBP2.

Jaipuria, Garima; Shet, Divya; Malik, Shahid; Swain, Monalisa; Atreya, Hanudatta S; Galea, Charles A; Slomiany, Mark G; Rosenzweig, Steven A; Forbes, Briony E; Norton, Raymond S; Mondal, Somnath

Jaipuria, Garima; Shet, Divya; Malik, Shahid; Swain, Monalisa; Atreya, Hanudatta S; Galea, Charles A; Slomiany, Mark G; Rosenzweig, Steven A; Forbes, Briony E; Norton, Raymond S; Mondal, Somnath.

Afiliação

Jaipuria G; NMR Research Centre, Indian Institute of Science, Bangalore, Karnataka, India.
Shet D; NMR Research Centre, Indian Institute of Science, Bangalore, Karnataka, India.
Malik S; Nanobiophysics Lab, Raman Research Institute, Sadashivnagar, Bangalore, Karnataka, India.
Swain M; NMR Research Centre, Indian Institute of Science, Bangalore, Karnataka, India.
Atreya HS; NMR Research Centre, Indian Institute of Science, Bangalore, Karnataka, India.
Galea CA; Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Rosenzweig SA; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Parkville, Australia.
Forbes BE; Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina, USA.
Norton RS; Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina, USA.
Mondal S; Flinders Health and Medical Research Institute, Flinders University, South Australia, Australia.

Proteins ; 90(9): 1732-1743, 2022 09.

Article em En | MEDLINE | ID: mdl-35443068

Assuntos

Proteína 2 de Ligação a Fator de Crescimento Semelhante à Insulina; Fator de Crescimento Insulin-Like I; Proteínas Intrinsicamente Desordenadas; Humanos; Proteína 2 de Ligação a Fator de Crescimento Semelhante à Insulina/metabolismo; Fator de Crescimento Insulin-Like I/metabolismo; Proteínas Intrinsicamente Desordenadas/metabolismo; Peptídeo Hidrolases/metabolismo; Ligação Proteica

Palavras-chave

NMR; conformational dynamics of intrinsically disordered protein; disordered protein; function-dynamics relationship of disordered protein; human IGF-binding protein-2; human insulin-like growth factor system; intrinsically disordered protein; protein-NMR; protein-protein interaction; proteolysis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Proteína 2 de Ligação a Fator de Crescimento Semelhante à Insulina / Proteínas Intrinsicamente Desordenadas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Proteins Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google