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Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme.
Distefano, Alessia; Caruso, Giuseppe; Oliveri, Valentina; Bellia, Francesco; Sbardella, Diego; Zingale, Gabriele Antonio; Caraci, Filippo; Grasso, Giuseppe.
Afiliação
  • Distefano A; Department of Chemical Sciences, University of Catania, Viale Andrea Doria 6, Catania 95125, Italy.
  • Caruso G; Department of Drug and Health Sciences, University of Catania, Viale Andrea Doria 6, Catania 95125, Italy.
  • Oliveri V; Oasi Research Institute-IRCCS, Via Conte Ruggero 73, Troina 94018, Italy.
  • Bellia F; Department of Chemical Sciences, University of Catania, Viale Andrea Doria 6, Catania 95125, Italy.
  • Sbardella D; Institute of Crystallography, CNR, Via Paolo Gaifami 18, Catania 95126, Italy.
  • Zingale GA; IRCSS-Fondazione Bietti, Rome 00198, Italy.
  • Caraci F; Department of Chemical Sciences, University of Catania, Viale Andrea Doria 6, Catania 95125, Italy.
  • Grasso G; Department of Drug and Health Sciences, University of Catania, Viale Andrea Doria 6, Catania 95125, Italy.
ACS Chem Neurosci ; 13(10): 1588-1593, 2022 05 18.
Article em En | MEDLINE | ID: mdl-35471926
l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carnosina / Fármacos Neuroprotetores / Insulisina Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carnosina / Fármacos Neuroprotetores / Insulisina Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália