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γδ T cell costimulatory ligands in antitumor immunity.
McGraw, Joseph M; Witherden, Deborah A.
Afiliação
  • McGraw JM; Department of Biology, Calibr at The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Witherden DA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Explor Immunol ; 2(1): 79-97, 2022.
Article em En | MEDLINE | ID: mdl-35480230
Antitumor immunity relies on the ability of T cells to recognize and kill tumor targets. γδ T cells are a specialized subset of T cells that predominantly localizes to non-lymphoid tissue such as the skin, gut, and lung where they are actively involved in tumor immunosurveillance. γδ T cells respond to self-stress ligands that are increased on many tumor cells, and these interactions provide costimulatory signals that promote their activation and cytotoxicity. This review will cover costimulatory molecules that are known to be critical for the function of γδ T cells with a specific focus on mouse dendritic epidermal T cells (DETC). DETC are a prototypic tissue-resident γδ T cell population with known roles in antitumor immunity and are therefore useful for identifying mechanisms that may control activation of other γδ T cell subsets within non-lymphoid tissues. This review concludes with a brief discussion on how γδ T cell costimulatory molecules can be targeted for improved cancer immunotherapy.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Explor Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Explor Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos