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Liposome Loaded Ion/Temperature Dual Responsive Gellan Gum Hydrogel as Potential Nasal-To-Brain Delivery System.
Zhou, Shuwen; Zheng, Xinmeng; Chen, Jun; Xu, Yiyang; Du, Xuancheng; Wang, Cheng; Cui, Pengfei; Qiu, Lin; Jiang, Pengju; Ni, Xinye; Wang, Jianhao.
Afiliação
  • Zhou S; The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213003, P. R. China.
  • Zheng X; School of Pharmacy, Changzhou University, Changzhou, 213164, P. R. China.
  • Chen J; School of Pharmacy, Changzhou University, Changzhou, 213164, P. R. China.
  • Xu Y; School of Pharmacy, Changzhou University, Changzhou, 213164, P. R. China.
  • Du X; School of Physics, Shandong University, Jinan, 250100, P. R. China.
  • Wang C; The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213003, P. R. China.
  • Cui P; The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213003, P. R. China.
  • Qiu L; School of Pharmacy, Changzhou University, Changzhou, 213164, P. R. China.
  • Jiang P; School of Pharmacy, Changzhou University, Changzhou, 213164, P. R. China.
  • Ni X; The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213003, P. R. China.
  • Wang J; School of Pharmacy, Changzhou University, Changzhou, 213164, P. R. China.
J Biomed Nanotechnol ; 18(2): 571-580, 2022 Feb 01.
Article em En | MEDLINE | ID: mdl-35484743
Intranasal administration, which can bypass the blood-brain barrier (BBB), is widely recognized as a promising strategy for high-efficiency drug delivery to the brain. Herein, for the purpose of effectively delivering drugs to the brain via intranasal administration, glutathione (GSH)-modified gellan gum (GSH-GG) with ion/temperature dual responsive properties was synthesized and encapsulated on galanthamine hydrobromide (GH)-loaded liposomes (GH-Lipo) for effective GH delivery to the brain (GH-Lipo@GSH-GG). Our results demonstrated that GSH-GG greatly decreased the gelation temperature of GG from 44.0 °C to 22.1 °C without compromising its ion responsiveness. Moreover, GSH-GG had a good protection ability for GH-loaded liposomes without affecting its drug release. Most importantly, the finally obtained GH-Lipo@GSHGG showed acceptable targeted delivery of GH to the brain upon in vivo administration. Therefore, this formulation can be employed as a potential delivery system in nasal-to-brain delivery.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Lipossomos Idioma: En Revista: J Biomed Nanotechnol Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Lipossomos Idioma: En Revista: J Biomed Nanotechnol Ano de publicação: 2022 Tipo de documento: Article