MicroRNA-29a-3p regulates chemosensitivity in hypopharyngeal carcinoma via targeting Cdc42.
Malays J Pathol
; 44(1): 53-60, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35484886
ABSTRACT
INTRODUCTION:
Hypopharyngeal carcinoma is one kind of high malignant tumour followed by poor prognosis in head and neck carcinomas. This study aimed to detect miR-29a-3p and Cdc42 in patients with hypopharyngeal carcinoma. MATERIALS ANDMETHODS:
The expression of miR-29a-3p and Cdc42 mRNA were detected, and the correlation between miR-29a-3p/Cdc42 and clinical stages was investigated.RESULTS:
The relative expression of miR-29a-3p in stage II, III and IV hypopharyngeal carcinoma tissues was significantly lower than that of stage I (P< 0.05). The relative expression of Cdc42 mRNA in stage I, III and IV tissues was significantly higher than that of stage I (P< 0.05). The expression of miR-29a-3p in hypopharyngeal carcinoma with lymph node metastasis was significantly lower than that without lymph node metastasis (P = 0.045).CONCLUSION:
MiR-29a-3p and Cdc42 mRNA could be potential diagnostic biomarkers of hypopharyngeal carcinoma.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
MicroRNAs
Limite:
Humans
Idioma:
En
Revista:
Malays J Pathol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China