Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment.
J Alzheimers Dis
; 87(4): 1695-1711, 2022.
Article
em En
| MEDLINE
| ID: mdl-35491784
ABSTRACT
BACKGROUND:
Several epidemiological studies report a negative association between Cancer and Alzheimer's disease (AD).OBJECTIVE:
To characterize the trajectories of memory loss in individuals with early amnestic cognitive impairment with and without history of previous cancer.METHODS:
Cognitive deterioration was assessed using the Montreal Cognitive Assessment (MoCA) or MoCA-Memory Index Score (MoCA-MIS) biannually in subjects with early amnestic cognitive impairment followed-up retrospectively from 2007 to 2021. History of Cancer was obtained from clinical records. Simple linear regressions of MoCA-MIS scores were calculated for each subject and analyzed with K-means cluster analysis to identify subgroups with different cognitive decline trajectories. χ2 and t tests were used for descriptive categorical and continuous variables and mixed multiple linear regressions to determine cognitive decline covariates.RESULTS:
Analysis of the trajectory of cognitive decline in 141 subjects with early amnestic cognitive impairment identified two subgroups Fast (nâ=â60) and Slow (nâ=â81) progressors. At baseline Fast progressors had better MoCA-MIS (pâ<â0.001) and functionality (CDR pâ=â0.02, AD8 pâ=â0.05), took less anti-dementia medications (pâ=â0.005), and had higher depression rates (pâ=â0.02). Interestingly, Fast progressors slowed their speed of memory decline (from 1.6 to 1.1 MoCA-MIS points/year) and global cognitive decline (from 2.0 to 1.4 total MoCA points/year) when Cancer history was present.CONCLUSION:
Two trajectories of amnestic cognitive decline were identified, possibly derived from different neurophysiopathologies or clinical stages. This study suggests that a history of previous Cancer slows down amnestic cognitive decline, specifically in a subgroup of subjects with depression at baseline and accelerated deterioration at follow-up.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
/
Disfunção Cognitiva
/
Neoplasias
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Chile