Chemical synthesis of the organoarsenical antibiotic arsinothricin.
RSC Adv
; 11(56): 35600-35606, 2021 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-35493177
ABSTRACT
We report two routes of chemical synthesis of arsinothricin (AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl protected derivative of hydroxyarsinothricin (AST-OH) and subsequent methylation of a trivalent arsenic intermediate with methyl iodide. The enzyme AST N-acetyltransferase (ArsN1) was utilized to purify l-AST from racemic AST. This chemical synthesis provides a source of this novel antibiotic for future drug development.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
RSC Adv
Ano de publicação:
2021
Tipo de documento:
Article