Assembly and function of branched ubiquitin chains.
Trends Biochem Sci
; 47(9): 759-771, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35508449
ABSTRACT
Post-translational modification with ubiquitin is required for cell division, differentiation, and survival in all eukaryotes. As part of an intricate signaling code, ubiquitin is attached to its targets as single molecules or polymeric chains, with the distinct modifications encoding a wide range of outcomes. After early work focused on homotypic ubiquitin chains, such as the K48-linked polymers that drive proteasomal degradation, recent studies noted abundant conjugates that contained ubiquitin molecules modified on two or more sites. Such branched ubiquitin chains are produced in response to specific signals and they exert functions that are critical for cellular and organismal homeostasis. In this review, we will discuss our rapidly evolving understanding of the assembly and function of branched ubiquitin chains.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Processamento de Proteína Pós-Traducional
/
Ubiquitina
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos