Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines.
RSC Adv
; 9(3): 1536-1540, 2019 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-35518015
ABSTRACT
A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.
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MEDLINE
Idioma:
En
Revista:
RSC Adv
Ano de publicação:
2019
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Article