Synthesis of Acyl Hydrazides via a Radical Chemistry of Azocarboxylic tert-Butyl Esters.
J Org Chem
; 87(10): 6573-6587, 2022 05 20.
Article
em En
| MEDLINE
| ID: mdl-35522737
ABSTRACT
A new chemistry of azo compounds, that is, addition of free radicals generated in situ to access various acyl hydrazides, has been developed. The protocol provides a novel strategy for the synthesis of valuable acyl hydrazides. The transformation features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. In view of the importance of acyl hydrazides in functional materials and medicinal chemistry, this approach would find broad applications.
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Base de dados:
MEDLINE
Assunto principal:
Ésteres
/
Hidrazinas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2022
Tipo de documento:
Article