Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds.
J Vet Med Sci
; 84(6): 872-876, 2022 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-35527018
ABSTRACT
Hyperplastic goblet cells and abundant mucus are significant characteristics of inflammatory colorectal polyps (ICRPs) in miniature dachshunds. In this study, selected mucin gene expressions and goblet cell proportions were evaluated in miniature dachshunds with ICRPs and in healthy dogs. Mucin 2 (MUC2) gene expression was not significantly different among the groups, whereas mucin 5AC (MUC5AC) gene expression was significantly higher in the polypoid lesions than in healthy colonic mucosa. Although the percentage of goblet cells in the upper crypt regions did not significantly differ between the groups, that in the lower crypt regions was significantly decreased in polypoid lesions. In conclusion, increased MUC5AC gene expression and goblet cell proportion changes may be associated with the pathogenesis of ICRPs.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pólipos do Colo
/
Doenças do Cão
Limite:
Animals
Idioma:
En
Revista:
J Vet Med Sci
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão