Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer.

Gu, Jianyou; Huang, Wenjie; Wang, Xianxing; Zhang, Junfeng; Tao, Tian; Zheng, Yao; Liu, Songsong; Yang, Jiali; Chen, Zhe-Sheng; Cai, Chao-Yun; Li, Jinsui; Wang, Huaizhi; Fan, Yingfang

Gu, Jianyou; Huang, Wenjie; Wang, Xianxing; Zhang, Junfeng; Tao, Tian; Zheng, Yao; Liu, Songsong; Yang, Jiali; Chen, Zhe-Sheng; Cai, Chao-Yun; Li, Jinsui; Wang, Huaizhi; Fan, Yingfang.

Afiliação

Gu J; Department of Hepatobiliary Surgery I, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Huang W; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
Wang X; Department of Hepatobiliary Surgery I, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Zhang J; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
Tao T; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
Zheng Y; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
Liu S; Department of Hepatobiliary Surgery I, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Yang J; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
Chen ZS; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
Cai CY; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
Li J; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA.
Wang H; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA.
Fan Y; Department of Hepatobiliary Surgery I, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Mol Cancer ; 21(1): 112, 2022 05 10.

Article em En | MEDLINE | ID: mdl-35538494

Assuntos

Transportadores de Cassetes de Ligação de ATP; Desoxicitidina; MicroRNAs; Neoplasias Pancreáticas; Fosfatidilinositol 3-Quinases; Proteínas Proto-Oncogênicas c-akt; Proteína rhoB de Ligação ao GTP; Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/metabolismo; Transportadores de Cassetes de Ligação de ATP/genética; Transportadores de Cassetes de Ligação de ATP/metabolismo; Animais; Linhagem Celular Tumoral; Desoxicitidina/análogos & derivados; Resistencia a Medicamentos Antineoplásicos; Humanos; MicroRNAs/genética; MicroRNAs/metabolismo; Simulação de Acoplamento Molecular; Proteínas de Neoplasias/metabolismo; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Proteína rhoB de Ligação ao GTP/metabolismo; Gencitabina; Neoplasias Pancreáticas

Palavras-chave

ABC transporters; Gemcitabine resistance; Hsa-miR-3178; PI3K/Akt; Pancreatic cancer; RhoB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Transportadores de Cassetes de Ligação de ATP / Fosfatidilinositol 3-Quinases / Proteína rhoB de Ligação ao GTP / MicroRNAs / Desoxicitidina / Proteínas Proto-Oncogênicas c-akt Limite: Animals / Humans Idioma: En Revista: Mol Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article

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