Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes.
J Clin Endocrinol Metab
; 107(8): 2216-2227, 2022 07 14.
Article
em En
| MEDLINE
| ID: mdl-35579171
ABSTRACT
CONTEXT Calorie restriction plus dietary advice is suggested as a preventive strategy for individuals with obesity and prediabetes; however, optimal diet is still debatable. We aimed to compare the effects of Mediterranean diet (MD) and Chinese diets high or low in plants on body weight and glucose homeostasis among high-risk Chinese. SUBJECTS AND METHODS:
In this parallel-arm randomized controlled trial, 253 Chinese adults aged 25 to 60 years with a body mass indexâ ≥â 24.0 kg/m2 and fasting blood glucoseâ ≥â 5.6 mmol/L were randomly assigned to 3 isocaloric-restricted diets MD (nâ =â 84), a traditional Jiangnan diet high in plants (TJD, nâ =â 85), or a control diet low in plants (CD, nâ =â 84). During the 6-month trial, a 5-weekday full-feeding regimen was followed, along with mobile app-based monitoring. Abdominal fat measurement (magnetic resonance imaging), oral glucose tolerance test (OGTT), and continuous glucose monitoring (CGM) were conducted at baseline and 3 and 6 months.RESULTS:
With a 25% calorie restriction for 6 months, weight deduction was 5.72 kg (95% confidence interval, 5.03-6.40) for MD, 5.05 kg (4.38-5.73) for TJD, and 5.38 kg (4.70-6.06) for CD (Ptimeâ <â 0.0001). No between-group differences were found for fasting glucose, insulin, and the Matsuda index from OGTT. Notably, CD had significantly longer time below range (glucoseâ <â 3.9 mmol/L) than MD (0.81% [0.21-1.40], Pâ =â 0.024) and marginally longer time than TJD (0.56% [-0.03 to 1.15], Pâ =â 0.065), as measured by CGM.CONCLUSIONS:
With the 6-month isocaloric-restricted feeding, TJD and MD achieved comparable weight deduction and improved glucose homeostasis, whereas CD showed a higher risk for hypoglycemia.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
/
Dieta Mediterrânea
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China