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Resonance Rayleigh scattering approach based on association complex formation with erythrosine B for determination of venlafaxine, application to the dosage form and spiked human plasma.
Mohammed, Bassam Shaaban; Derayea, Sayed M; Hassan, Yasser F; A Abu-Hassan, Ahmed.
Afiliação
  • Mohammed BS; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Derayea SM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Hassan YF; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
  • A Abu-Hassan A; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
Luminescence ; 37(7): 1215-1222, 2022 Jul.
Article em En | MEDLINE | ID: mdl-35582967
The interaction of venlafaxine hydrochloride (VLX) with erythrosine B was investigated using a resonance Rayleigh scattering (RRS) spectroscopic technique. In acetate buffer (pH 3.4), erythrosine B reacted with VLX to form a 1:1 ion-pair complex with concomitant enhancement in RRS intensity that was measured at 330 nm. In addition, the stability constant and the change in free energy of the reaction were estimated. Based on this interaction a new method was developed for a sensitive VLX analysis using erythrosine B as a probe. The results indicated that this method had good selectivity in the presence of coexisting compounds. The scattering intensity (ΔIRRS ) was linearly dependent on VLX concentration over the range 0.04-1.0 µg ml-1 with a determination coefficient (r) of 0.9998. The limit of detection and limit of quantitation were 0.01 and 0.03 µg ml-1 , respectively. This method could be suitably used for analysis of VLX in pharmaceutical capsules and human plasma.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eritrosina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Luminescence Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eritrosina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Luminescence Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito