Amidoxime functionalized chitosan for uranium sequestration in vivo.
Ecotoxicol Environ Saf
; 239: 113636, 2022 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-35588624
ABSTRACT
Amidoxime functionalized chitosan (AC) was recommended as a chelator for uranium sequestration in vivo in this study, and the structure-activity relationship was also explored. Compared with ZnNa3-DTPA, which was a commercial uranium mobilization drug, AC exhibited excellent biocompatibility and uranium removal efficiency, whether by injection or orally, which could reduce the amounts of uranium deposited in kidneys and femurs by up to 43.6% and 32.3%. In particular, ACs still possessed the ability to mobilize uranium in vivo even if administration was delayed for 72 h.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Urânio
/
Quitosana
Idioma:
En
Revista:
Ecotoxicol Environ Saf
Ano de publicação:
2022
Tipo de documento:
Article