Neuroprotective effects of combined trimetazidine and progesterone on cerebral reperfusion injury.

Dhote, Vipin; Mandloi, Avinash Singh; Singour, Pradeep Kumar; Kawadkar, Manisha; Ganeshpurkar, Aditya; Jadhav, Manoj P

Dhote, Vipin; Mandloi, Avinash Singh; Singour, Pradeep Kumar; Kawadkar, Manisha; Ganeshpurkar, Aditya; Jadhav, Manoj P.

Afiliação

Dhote V; Faculty of Pharmacy, VNS Group of Institutions, Bhopal, MP, India.
Mandloi AS; Faculty of Pharmacy, VNS Group of Institutions, Bhopal, MP, India.
Singour PK; Faculty of Pharmacy, VNS Group of Institutions, Bhopal, MP, India.
Kawadkar M; Faculty of Pharmacy, VNS Group of Institutions, Bhopal, MP, India.
Ganeshpurkar A; Department of Pharmacy, Shri Ram Institute of Technology, Jabalpur, MP, India.
Jadhav MP; Isha Therapeutics LLC, 300, Parsippany Road, Parsippany, NJ, United States.

Curr Res Pharmacol Drug Discov ; 3: 100108, 2022.

Article em En | MEDLINE | ID: mdl-35602337

Palavras-chave

3-KAT, 3-Ketoacyl coenzyme A thiolase; AQP4, Aquaporin; Apaf-1, Apoptotic protease activating factor-1; Apoptosis; BBB, Blood brain barrier; CAT, Catalase; DTNB, 5-,5-dithiobis 2-nitrobenzoic acid; FFA, Free fatty acid; GSH, Reduced glutahione; I/R, Ischemia-reperfusion; IL-1ß, Interleukin 1beta; Ischemia-reperfusion; MCAO, Middle cerebral artery occlusion; MDA, Malondialdehyde; MPO, Myeloperoxidase; Metabolic energy; Molecular docking; Myeloperoxidase; Oxidative stress; PG, Progesterone; ROCK, Rho/Rho-kinase; SOD, Superoxide dismutase; TBA, Thiobarbituric acid; TCA, Trichloroacetic acid; TMZ, Trimetazidine; TNFα, Tumor necrosis factor-alpha; TTC, 2,3,5-triphenyl-tetrazolium chloride; mptp, Mitochondrial pore permeability

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Curr Res Pharmacol Drug Discov Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

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