PD-L1 expression and overall survival in Asian and western patients with gastric cancer.
Future Oncol
; 18(21): 2623-2634, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35616013
ABSTRACT
Aim:
Data are limited on PD-L1 expression and its association with overall survival (OS) in gastric cancer (GC) patients receiving routine care in different regions. Materials &methods:
In a retrospective study, PD-L1 expression was assayed using the 22C3 pharmDx on GC tumor samples collected between 2003 and 2017 at South Korean and US cancer centers. PD-L1 positivity was defined as combined positive score (CPS) ≥1. The relationship between PD-L1 and OS was analyzed.Results:
Of 574 GC tumor samples, 67.4% were CPS ≥1 (68.7% in Korean and 65.7% in US patients). PD-L1 expression was not associated with OS (adjusted hazard ratio 0.94; 95% CI 0.75-1.17).Conclusion:
PD-L1 prevalence and its association with OS was similar between South Korean and US GC patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Antígeno B7-H1
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2022
Tipo de documento:
Article