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MRI-based Texture Analysis of Infrapatellar Fat Pad to Predict Knee Osteoarthritis Incidence.
Li, Jia; Fu, Shuai; Gong, Ze; Zhu, Zhaohua; Zeng, Dong; Cao, Peihua; Lin, Ting; Chen, Tianyu; Wang, Xiaoshuai; Lartey, Richard; Kwoh, C Kent; Guermazi, Ali; Roemer, Frank W; Hunter, David J; Ma, Jianhua; Ding, Changhai.
Afiliação
  • Li J; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Fu S; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Gong Z; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Zhu Z; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Zeng D; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Cao P; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Lin T; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Chen T; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Wang X; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Lartey R; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Kwoh CK; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Guermazi A; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Roemer FW; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Hunter DJ; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Ma J; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
  • Ding C; From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering,
Radiology ; 304(3): 611-621, 2022 09.
Article em En | MEDLINE | ID: mdl-35638929
ABSTRACT
Background Infrapatellar fat pad (IPFP) quality has been implicated as a marker for predicting knee osteoarthritis (KOA); however, no valid quantification for subtle IPFP abnormalities has been established. Purpose To investigate whether MRI-based three-dimensional texture analysis of IPFP abnormalities could help predict incident radiographic KOA. Materials and Methods In this prospective nested case-control study, 690 participants whose knees were at risk for KOA were included from the Pivotal Osteoarthritis Initiative MRI Analyses incident osteoarthritis cohort. All knees had a Kellgren-Lawrence grade of 1 or less at baseline. During the 4-year follow-up, case participants were matched 11 to control participants, with incident radiographic KOA as the outcome. MRI scans were segmented at the incident time point of KOA (hereafter, P0), 1 year before P0 (hereafter, P-1), and baseline. MRI-based three-dimensional texture analysis was performed to extract IPFP texture features. Least absolute shrinkage and selection operator and multivariable logistic regressions were applied in the development cohort and evaluated in the test cohort. The area under the receiver operating characteristic curve (AUC) was used to evaluate the discriminative value of the clinical score, IPFP texture score, and MRI Osteoarthritis Knee Score. Results Participants were allocated to development (n = 500, 340 women; mean age, 60 years) and test (n = 190, 120 women; mean age, 61 years) cohorts. In both cohorts, IPFP texture scores (AUC ≥0.75 for all) showed greater discrimination than clinical scores (AUC ≤0.69 for all) at baseline, P-1, and P0, with significant differences in pairwise comparisons (P ≤ .002 for all). Greater predictive and concurrent validities of IPFP texture scores (AUC ≥0.75 for all) compared with MRI Osteoarthritis Knee Scores (AUC ≤0.66 for all) were also demonstrated (P < .001 for all). Conclusion MRI-based three-dimensional texture of the infrapatellar fat pad was associated with future development of knee osteoarthritis. ClinicalTrials.gov registration no. NCT00080171 © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Fischer in this issue.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite do Joelho Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite do Joelho Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Ano de publicação: 2022 Tipo de documento: Article