CXCR2 antagonist SB332235 mitigates deficits in social behavior and dysregulation of Th1/Th22 and T regulatory cell-related transcription factor signaling in male BTBR T<sup>+</sup> Itpr3<sup>tf</sup>/J mouse model of autism.

Albekairi, Norah A; Nadeem, Ahmed; Ansari, Mushtaq A; Attia, Sabry M; Bakheet, Saleh A; Alanazi, Mohammed M; Alhamed, Abdullah S; Albekairi, Thamer H; Al-Mazroua, Haneen A; Ibrahim, Khalid E; Ahmad, Sheikh F

CXCR2 antagonist SB332235 mitigates deficits in social behavior and dysregulation of Th1/Th22 and T regulatory cell-related transcription factor signaling in male BTBR T⁺ Itpr3^tf/J mouse model of autism.

Albekairi, Norah A; Nadeem, Ahmed; Ansari, Mushtaq A; Attia, Sabry M; Bakheet, Saleh A; Alanazi, Mohammed M; Alhamed, Abdullah S; Albekairi, Thamer H; Al-Mazroua, Haneen A; Ibrahim, Khalid E; Ahmad, Sheikh F.

Afiliação

Albekairi NA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Nadeem A; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Ansari MA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Attia SM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Bakheet SA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alanazi MM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alhamed AS; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Albekairi TH; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Al-Mazroua HA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Ibrahim KE; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Ahmad SF; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: fashaikh@ksu.edu.sa.

Pharmacol Biochem Behav ; 217: 173408, 2022 06.

Article em En | MEDLINE | ID: mdl-35644272

Assuntos

Transtorno Autístico; Receptores de Interleucina-8B; Comportamento Social; Sulfonamidas; Linfócitos T Reguladores; Animais; Citocinas/metabolismo; Modelos Animais de Doenças; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos; RNA Mensageiro/metabolismo; Receptores de Interleucina-8B/antagonistas & inibidores; Receptores de Interleucina-8B/metabolismo; Transdução de Sinais/efeitos dos fármacos; Sulfonamidas/farmacologia; Linfócitos T Reguladores/efeitos dos fármacos; Linfócitos T Reguladores/metabolismo; Células Th1/efeitos dos fármacos; Células Th1/metabolismo; Células Th1/patologia

Palavras-chave

Autism spectrum disorders; BTBR mice; C57 mice; CXCR2 antagonist; SB332235; Th1/Th22/Treg cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Comportamento Social / Sulfonamidas / Linfócitos T Reguladores / Receptores de Interleucina-8B Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Pharmacol Biochem Behav Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita

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