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A tissue-like neurotransmitter sensor for the brain and gut.
Li, Jinxing; Liu, Yuxin; Yuan, Lei; Zhang, Baibing; Bishop, Estelle Spear; Wang, Kecheng; Tang, Jing; Zheng, Yu-Qing; Xu, Wenhui; Niu, Simiao; Beker, Levent; Li, Thomas L; Chen, Gan; Diyaolu, Modupeola; Thomas, Anne-Laure; Mottini, Vittorio; Tok, Jeffrey B-H; Dunn, James C Y; Cui, Bianxiao; Pașca, Sergiu P; Cui, Yi; Habtezion, Aida; Chen, Xiaoke; Bao, Zhenan.
Afiliação
  • Li J; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
  • Liu Y; Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
  • Yuan L; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Zhang B; Department of Biology, Stanford University, Stanford, CA, USA.
  • Bishop ES; Department of Biology, Stanford University, Stanford, CA, USA.
  • Wang K; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.
  • Tang J; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
  • Zheng YQ; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
  • Xu W; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
  • Niu S; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
  • Beker L; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
  • Li TL; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
  • Chen G; Department of Chemistry, Stanford University, Stanford, CA, USA.
  • Diyaolu M; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Thomas AL; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
  • Mottini V; Department of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
  • Tok JB; Department of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
  • Dunn JCY; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
  • Cui B; Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
  • Pașca SP; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
  • Cui Y; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Habtezion A; Department of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
  • Chen X; Department of Chemistry, Stanford University, Stanford, CA, USA.
  • Bao Z; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Nature ; 606(7912): 94-101, 2022 06.
Article em En | MEDLINE | ID: mdl-35650358
Neurotransmitters play essential roles in regulating neural circuit dynamics both in the central nervous system as well as at the peripheral, including the gastrointestinal tract1-3. Their real-time monitoring will offer critical information for understanding neural function and diagnosing disease1-3. However, bioelectronic tools to monitor the dynamics of neurotransmitters in vivo, especially in the enteric nervous systems, are underdeveloped. This is mainly owing to the limited availability of biosensing tools that are capable of examining soft, complex and actively moving organs. Here we introduce a tissue-mimicking, stretchable, neurochemical biological interface termed NeuroString, which is prepared by laser patterning of a metal-complexed polyimide into an interconnected graphene/nanoparticle network embedded in an elastomer. NeuroString sensors allow chronic in vivo real-time, multichannel and multiplexed monoamine sensing in the brain of behaving mouse, as well as measuring serotonin dynamics in the gut without undesired stimulations and perturbing peristaltic movements. The described elastic and conformable biosensing interface has broad potential for studying the impact of neurotransmitters on gut microbes, brain-gut communication and may ultimately be extended to biomolecular sensing in other soft organs across the body.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Sistema Nervoso Entérico / Neurotransmissores / Trato Gastrointestinal Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Sistema Nervoso Entérico / Neurotransmissores / Trato Gastrointestinal Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos