Structural basis for the inhibition of human angiotensin-1 converting enzyme by fosinoprilat.

Cozier, Gyles E; Newby, Emma C; Schwager, Sylva L U; Isaac, R Elwyn; Sturrock, Edward D; Acharya, K Ravi

Cozier, Gyles E; Newby, Emma C; Schwager, Sylva L U; Isaac, R Elwyn; Sturrock, Edward D; Acharya, K Ravi.

Afiliação

Cozier GE; Department of Biology and Biochemistry, University of Bath, UK.
Newby EC; Department of Biology and Biochemistry, University of Bath, UK.
Schwager SLU; Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Isaac RE; School of Biology, University of Leeds, UK.
Sturrock ED; Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Acharya KR; Department of Biology and Biochemistry, University of Bath, UK.

FEBS J ; 289(21): 6659-6671, 2022 11.

Article em En | MEDLINE | ID: mdl-35653492

Assuntos

Inibidores da Enzima Conversora de Angiotensina; Peptidil Dipeptidase A; Humanos; Peptidil Dipeptidase A/química; Cristalografia por Raios X; Inibidores da Enzima Conversora de Angiotensina/química; Angiotensinas

Palavras-chave

X-ray crystallography; angiotensin-1-converting enzyme; domain selectivity; enzyme structure; inhibitor binding; metalloprotease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Enzima Conversora de Angiotensina / Peptidil Dipeptidase A Limite: Humans Idioma: En Revista: FEBS J Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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