Worse Outcome with Imatinib Mesylate as Neoadjuvant Therapy in Locally Advanced Rectal Gastrointestinal Stromal Tumors: Case Series of Four Patients.
Gulf J Oncolog
; 1(39): 27-30, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-35695343
ABSTRACT
BACKGROUND:
Rectal gastrointestinal stromal tumors are rare and optimal treatment is yet to be defined. The aim of this report is to highlight the possible aggressive behavior of four cases of rectal GISTs treated with neoadjuvant imatinib in a tertiary care medical hospital.METHODS:
Four cases of rectal GISTs were retrospectively reviewed for patients demographics, clinical presentation, histology, and imatinib therapy.RESULTS:
GISTs were common in men. Age ranged to symptoms were nonspecific. All cases were initially considered to have locally unresectable. Patients received preoperative imatinib. Course was unfavorable. 3 patients died of progressive disease, and one from infectious complications.CONCLUSION:
Rectal GISTs may be aggressive and resistant to medical treatment. Thus only early diagnosis may offer the best chance of recovery. KEY WORDS Rectal - gastrointestinal stromal tumor - neoadjuvant imatinib - resistance.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Tumores do Estroma Gastrointestinal
/
Antineoplásicos
Tipo de estudo:
Observational_studies
/
Screening_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Gulf J Oncolog
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Marrocos