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3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity.
Zheng, Yang; Müller, Joachim; Kunz, Stefan; Siderius, Marco; Maes, Louis; Caljon, Guy; Müller, Norbert; Hemphill, Andrew; Sterk, Geert Jan; Leurs, Rob.
Afiliação
  • Zheng Y; Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands.
  • Müller J; Vetsuisse Faculty, Institute of Parasitology, University of Bern, Länggass-Strasse 122, CH-3012, Bern, Switzerland.
  • Kunz S; Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands; Vetsuisse Faculty, Institute of Parasitology, University of Bern, Länggass-Strasse 122, CH-3012, Bern,
  • Siderius M; Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands.
  • Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium.
  • Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium.
  • Müller N; Vetsuisse Faculty, Institute of Parasitology, University of Bern, Länggass-Strasse 122, CH-3012, Bern, Switzerland.
  • Hemphill A; Vetsuisse Faculty, Institute of Parasitology, University of Bern, Länggass-Strasse 122, CH-3012, Bern, Switzerland.
  • Sterk GJ; Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands.
  • Leurs R; Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands. Electronic address: r.leurs@vu.nl.
Int J Parasitol Drugs Drug Resist ; 19: 47-55, 2022 08.
Article em En | MEDLINE | ID: mdl-35716585
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Trypanosoma brucei brucei / Giardíase / Giardia lamblia / Doença de Chagas Limite: Humans Idioma: En Revista: Int J Parasitol Drugs Drug Resist Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Trypanosoma brucei brucei / Giardíase / Giardia lamblia / Doença de Chagas Limite: Humans Idioma: En Revista: Int J Parasitol Drugs Drug Resist Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda