Mice expressing P301S mutant human tau have deficits in interval timing.
Behav Brain Res
; 432: 113967, 2022 08 26.
Article
em En
| MEDLINE
| ID: mdl-35718229
ABSTRACT
Interval timing is a key executive process that involves estimating the duration of an interval over several seconds or minutes. Patients with Alzheimer's disease (AD) have deficits in interval timing. Since temporal control of action is highly conserved across mammalian species, studying interval timing tasks in animal AD models may be relevant to human disease. Amyloid plaques and tau neurofibrillary tangles are hallmark features of AD. While rodent models of amyloid pathology are known to have interval timing impairments, to our knowledge, interval timing has not been studied in models of tauopathy. Here, we evaluate interval timing performance of P301S transgenic mice, a widely studied model of tauopathy that overexpresses human tau with the P301S mutation. We employed an interval timing task and found that P301S mice consistently underestimated temporal intervals compared to wild-type controls, responding early in anticipation of the target interval. Our study indicating timing deficits in a mouse tauopathy model could have relevance to human tauopathies such as AD.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tauopatias
/
Doença de Alzheimer
Limite:
Animals
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Humans
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos