Bioinspired Palladium-Catalyzed Intramolecular C(sp3 )-H Activation for the Collective Synthesis of Proline Natural Products.
Angew Chem Int Ed Engl
; 61(33): e202207088, 2022 08 15.
Article
em En
| MEDLINE
| ID: mdl-35751877
Bioinspired palladium-catalyzed intramolecular cyclization of amino acid derivatives containing a vinyl iodide moiety by C-H activation enabled rapid access to a wide range of functionalized proline derivatives with an exocyclic olefin. To demonstrate the practicality of this methodology, the functionalized prolines were used as intermediates for the synthesis of several natural products: lucentamycin A, oxotomaymycin, oxoprothracarcin, and barmumycin.
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Produtos Biológicos
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Angew Chem Int Ed Engl
Ano de publicação:
2022
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Article