Established and Emerging Therapies in Acute Spinal Cord Injury.
Neurospine
; 19(2): 283-296, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35793931
ABSTRACT
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20-50 per million people. Following initial assessment with appropriate physical examination and imaging, patients who are deemed surgical candidates should undergo decompression with stabilization. Earlier intervention can improve neurological recovery in the post-operative period while allowing earlier mobilization. Optimized medical management is paramount to improve outcomes. Emerging strategies for managing SCI in the acute period stem from an evolving understanding of the pathophysiology of the injury. General areas of focus include ischemia prevention, reduction of secondary injury due to inflammation, modulation of the cytotoxic and immune response, and promotion of cellular regeneration. In this article, we review established, emerging, and novel experimental therapies. Continued translational research on these methods will improve the feasibility of bench-to-bedside innovations in treating patients with acute SCI.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Neurospine
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos