Time to re-evaluate the risks and benefits of valproate and a call for action.

Howes, Oliver D; Barnes, Thomas R E; Lennox, Belinda R; Markham, Sarah; Natesan, Sridhar

Howes, Oliver D; Barnes, Thomas R E; Lennox, Belinda R; Markham, Sarah; Natesan, Sridhar.

Afiliação

Howes OD; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; and Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, UK.
Barnes TRE; Faculty of Medicine, Department of Brain Sciences, Imperial College London, UK.
Lennox BR; Department of Psychiatry, University of Oxford, UK.
Markham S; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Natesan S; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; and Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, UK.

Br J Psychiatry ; 221(6): 711-713, 2022 12.

Article em En | MEDLINE | ID: mdl-35795925

ABSTRACT

ABSTRACT

Valproate is widely used in psychiatry and neurology, including off-label use. Here we consider its potential benefits and risks, particularly for women of childbearing potential, and the evidence that clinical guidelines are adhered to. Finally, we consider the implications for clinical practice and research into its efficacy in off-label indications.

Assuntos

Anticonvulsivantes; Ácido Valproico; Feminino; Humanos; Ácido Valproico/efeitos adversos; Anticonvulsivantes/efeitos adversos; Medição de Risco

Palavras-chave

anticonvulsants; drug interactions and side-effects; education and training; polypharmacy; psychotic disorders

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Valproico / Anticonvulsivantes Tipo de estudo: Etiology_studies / Guideline / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Br J Psychiatry Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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