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Factors associated with sick leave duration in patients suffering from major depressive disorder initiating antidepressant treatment: a real-world evidence study in Germany and Spain.
Roca, Miquel; Bonelli, Annalisa; Cattaneo, Agnese; Comandini, Alessandro; Di Dato, Giorgio; Heiman, Franca; Pegoraro, Valeria; Kasper, Siegfried; Volz, Hans-Peter; Palao, Diego.
Afiliação
  • Roca M; Department of Medicine, IUNICS/IDISBA, University of Balearic Islands, Palma, Spain.
  • Bonelli A; Angelini Pharma S.p.A., Rome, Italy.
  • Cattaneo A; Angelini Pharma S.p.A., Rome, Italy.
  • Comandini A; Angelini Pharma S.p.A., Rome, Italy.
  • Di Dato G; Angelini Pharma S.p.A., Rome, Italy.
  • Heiman F; IQVIA Solutions Italy S.r.l., RWS, Milan, Italy.
  • Pegoraro V; IQVIA Solutions Italy S.r.l., RWS, Milan, Italy.
  • Kasper S; Center for Brain Research, Medical University of Vienna, Vienna, Austria.
  • Volz HP; Hospital for Psychiatry, Psychotherapy and Psychosomatic Medicine, Werneck, Germany.
  • Palao D; Department of Mental Health, Parc Taulí-University Hospital of Sabadell, Sabadell, Spain.
Int J Psychiatry Clin Pract ; 27(1): 59-68, 2023 Mar.
Article em En | MEDLINE | ID: mdl-35801359
ABSTRACT

OBJECTIVE:

To describe MDD patients starting antidepressant (AD) treatment by pharmacological approach and identify factors associated with a longer sick leave (SL) duration.

METHODS:

Retrospective study on IQVIA German Disease Analyser (specialists) and Spanish Longitudinal Patient Database (general practitioners and specialists). MDD patients initiating AD treatment between July 2016-June 2018 were grouped by therapeutic approach (AD monotherapy vs. combination/switch/add-on) and their characteristics were analysed descriptively. Multiple logistic regression models were run to evaluate factors affecting SL duration (i.e., >30 days).

RESULTS:

One thousand six hundred and eighty-five patients (monotherapy 58%; combination/switch/add-on 42%) met inclusion criteria for Germany, and 1817 for Spain (monotherapy 83%; combination/switch/add-on 17%). AD treatment influenced SL duration combination/switch/add-on patients had a 2-fold and a 4-fold risk of having >30 days of SL than monotherapy patients, respectively in Germany and Spain. Patients with a gap of time between MDD diagnosis and AD treatment initiation had a higher likelihood of experiencing a longer SL both in Germany and Spain (38% higher likelihood and 6-fold risk of having >30 days of SL, respectively).

CONCLUSIONS:

A careful and timely selection of AD treatment approach at the time of MDD diagnosis may improve functional recovery and help to reduce SL, minimising the socio-economic burden of the disease.Key pointsThe major depressive disorder has a substantial impact on work absenteeism.The present study aimed to describe MDD patients starting antidepressant (AD) treatment depending on the pharmacological approach and to identify factors associated with longer sick leave (SL) duration.Patients receiving AD monotherapy had a lower likelihood of having more than 30 days of sick leave than those receiving AD combination/switch/add-on.Patients for whom a gap of time between MDD diagnosis and initiation of AD treatment was observed, showed a higher likelihood of having more than 30 days of sick leave.Because findings from this analysis relied on secondary data, the authors would like to claim the urgency of conducting prospective observational studies that further investigate the effect that different AD therapeutic approaches and timely initiation of treatment might exert on patients' recovery.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Int J Psychiatry Clin Pract Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Int J Psychiatry Clin Pract Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha