Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability.

Renaud, Eléa A; Pamukcu, Sarah; Cerutti, Aude; Berry, Laurence; Lemaire-Vieille, Catherine; Yamaryo-Botté, Yoshiki; Botté, Cyrille Y; Besteiro, Sébastien

Renaud, Eléa A; Pamukcu, Sarah; Cerutti, Aude; Berry, Laurence; Lemaire-Vieille, Catherine; Yamaryo-Botté, Yoshiki; Botté, Cyrille Y; Besteiro, Sébastien.

Afiliação

Renaud EA; LPHI, University of Montpellier, CNRS, UMR5235, Montpellier, France.
Pamukcu S; LPHI, University of Montpellier, CNRS, UMR5235, Montpellier, France.
Cerutti A; LPHI, University of Montpellier, CNRS, UMR5235, Montpellier, France.
Berry L; LPHI, University of Montpellier, CNRS, UMR5235, Montpellier, France.
Lemaire-Vieille C; ApicoLipid Team, Centre National de la Recherche Scientifique, Institute for Advanced Biosciences, Institut National de la Santé et de la Recherche Médicale, UMR5309, U1209, Université Grenoble Alpes, Grenoble, France.
Yamaryo-Botté Y; ApicoLipid Team, Centre National de la Recherche Scientifique, Institute for Advanced Biosciences, Institut National de la Santé et de la Recherche Médicale, UMR5309, U1209, Université Grenoble Alpes, Grenoble, France.
Botté CY; ApicoLipid Team, Centre National de la Recherche Scientifique, Institute for Advanced Biosciences, Institut National de la Santé et de la Recherche Médicale, UMR5309, U1209, Université Grenoble Alpes, Grenoble, France.
Besteiro S; LPHI, University of Montpellier, CNRS, UMR5235, Montpellier, France. Electronic address: sebastien.besteiro@inserm.fr.

J Biol Chem ; 298(8): 102243, 2022 08.

Article em En | MEDLINE | ID: mdl-35810787

Assuntos

Apicoplastos; Proteínas Ferro-Enxofre; Proteínas de Protozoários; Toxoplasma; Apicoplastos/genética; Apicoplastos/metabolismo; Ácidos Graxos/metabolismo; Proteínas Ferro-Enxofre/genética; Proteínas Ferro-Enxofre/metabolismo; Plastídeos/genética; Proteínas de Protozoários/genética; Proteínas de Protozoários/metabolismo; Terpenos/metabolismo; Toxoplasma/genética; Toxoplasma/metabolismo

Palavras-chave

Toxoplasma gondii; apicoplast; iron metabolism; iron-sulfur protein; lipid; parasite metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma / Proteínas de Protozoários / Apicoplastos / Proteínas Ferro-Enxofre Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França

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