Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with diarylpropionitrile (DPN) or DPN derivatives.

Handa, Chiaki; Yamazaki, Yuki; Yonekubo, Shigeru; Furuya, Noritaka; Momose, Takaki; Ozawa, Tomonaga; Furuishi, Takayuki; Fukuzawa, Kaori; Yonemochi, Etsuo

Handa, Chiaki; Yamazaki, Yuki; Yonekubo, Shigeru; Furuya, Noritaka; Momose, Takaki; Ozawa, Tomonaga; Furuishi, Takayuki; Fukuzawa, Kaori; Yonemochi, Etsuo.

Afiliação

Handa C; Central Research Laboratory, Kissei Pharmaceutical Co., Ltd., 4365-1, Hotakakashiwabara, Azumino, Nagano 399-8304, Japan; School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Shinagawa, Tokyo 142-8501, Japan. Electronic address: chiaki_handa@pharm.kissei.co.jp.
Yamazaki Y; School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
Yonekubo S; Central Research Laboratory, Kissei Pharmaceutical Co., Ltd., 4365-1, Hotakakashiwabara, Azumino, Nagano 399-8304, Japan.
Furuya N; Central Research Laboratory, Kissei Pharmaceutical Co., Ltd., 4365-1, Hotakakashiwabara, Azumino, Nagano 399-8304, Japan.
Momose T; Central Research Laboratory, Kissei Pharmaceutical Co., Ltd., 4365-1, Hotakakashiwabara, Azumino, Nagano 399-8304, Japan.
Ozawa T; Central Research Laboratory, Kissei Pharmaceutical Co., Ltd., 4365-1, Hotakakashiwabara, Azumino, Nagano 399-8304, Japan.
Furuishi T; School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
Fukuzawa K; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yonemochi E; School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Shinagawa, Tokyo 142-8501, Japan.

J Steroid Biochem Mol Biol ; 222: 106152, 2022 09.

Article em En | MEDLINE | ID: mdl-35810932

Assuntos

Receptor alfa de Estrogênio; Receptor beta de Estrogênio; Calorimetria; Cloro; Estradiol; Receptor alfa de Estrogênio/metabolismo; Receptor beta de Estrogênio/metabolismo; Ligantes; Nitrilas; Propionatos

Palavras-chave

Diarylpropionitrile; Estrogen receptor ß; Fragment molecular orbital method; Isothermal titration calorimetry; Protein-ligand interaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor alfa de Estrogênio / Receptor beta de Estrogênio Idioma: En Revista: J Steroid Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article

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