Durable response in a patient with recurrent respiratory papillomatosis treated with immune checkpoint blockade.
Head Neck
; 44(10): E31-E37, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35815785
ABSTRACT
BACKGROUND:
Immune checkpoint blockade can provide clinical benefit for patients with advanced cancer. Here, we report durable disease control over many years following PD-L1 blockade through induction of a viral antigen-specific T cell response in an adult patient with recurrent respiratory papillomatosis.METHODS:
Antigen-specific T cell response assays, single cell RNA-sequencing, and RNA-scope was used to study clinical tissues.RESULTS:
An HPV6 E2-specific T cell clone restricted to HLA-B*55, present at low frequency in the pre-treatment papilloma, significantly expanded after six doses of PD-L1 blockade and remained present and functional at the site of initial response in the larynx as a tissue resident memory T cell for 4 years. An associated reduction in E2 target gene was observed following treatment.CONCLUSIONS:
Although demonstrated in a single exceptional responder, these results highlight that immune checkpoint blockade may induce durable, viral antigen-specific immunity of sufficient magnitude to control disease in patients with nonmalignant disorders.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Papiloma
/
Antígeno B7-H1
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Head Neck
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos