Ditans: a new prospective for the therapy of migraine attack?
Neurol Sci
; 43(9): 5709-5716, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35816257
ABSTRACT
INTRODUCTION:
Migraine attack is characterized by disabling pain and associated symptoms. Triptans represent the "gold standard" therapy, but cardiac subjects have significant limitations for this approach. New drug families are under consideration to expand therapeutic offerings, especially in the presence of contraindications or for non-responsive patients. This review aimed to analyze studies related to the category of "ditans," with a focus on lasmiditan, which is available for human use. MATERIALS ANDMETHODS:
We consulted PubMed/MEDLINE, Web of Science, and www. CLINICALTRIALS gov to find both original and review articles on the mechanism of action of 5-HT1F agonists in migraine, and for randomized, double-blind, placebo-controlled trials (RCTs) on the family of drugs called "ditans," with a focus on "lasmiditan," published in the time frame of 01-Jan-2010 to 31-Mar-2022. Only studies conducted in human subjects and published in English were included in this review.RESULTS:
We retrieved four RCTs (named SAMURAI, SPARTAN, GLADIATOR, and CENTURION) and several studies that analyzed the efficacy and safety of lasmiditan. Lasmiditan at increasing doses showed significant improvement in pain and most other troublesome symptoms at 2 h. Adverse events were mild and mainly represented by dizziness, vertigo, drowsiness, and fatigue. No vasoconstrictive effects were described, suggesting the use of ditans as a safe option in chronic cardio- and cerebro-vascular disease.DISCUSSION:
Lasmiditan could be a viable alternative to triptans, although further RCT studies and real-world evidence are needed to better understand its potential and possible adverse events in a larger population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Agonistas do Receptor de Serotonina
/
Transtornos de Enxaqueca
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
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Observational_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Neurol Sci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália