Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance.
J Exp Clin Cancer Res
; 41(1): 218, 2022 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-35821160
ABSTRACT
Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields meaningful insights into potential biomarkers and therapeutic targets. Covalently closed circular RNAs (circRNAs) have emerged as crucial regulators in diverse human cancers including GC. Furthermore, accumulating evidence has demonstrated that circRNAs exhibit the dysregulated patterns in GC and have emerged as crucial regulators in GC invasion and metastasis. However, systematic knowledge regarding the involvement of circRNAs in metastatic GC remains obscure. In this review, we outline the functional circRNAs related to GC metastasis and drug resistance and discuss their underlying mechanisms, providing a comprehensive delineation of circRNA functions on metastatic GC and shedding new light on future therapeutic interventions for GC metastases.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
RNA Circular
Limite:
Humans
Idioma:
En
Revista:
J Exp Clin Cancer Res
Ano de publicação:
2022
Tipo de documento:
Article