A Chimeric Penicillin Binding Protein 2X Significantly Decreases in Vitro Beta-Lactam Susceptibility and Increases in Vivo Fitness of Streptococcus pyogenes.

Olsen, Randall J; Zhu, Luchang; Mangham, Regan E; Faili, Ahmad; Kayal, Samer; Beres, Stephen B; Musser, James M

A Chimeric Penicillin Binding Protein 2X Significantly Decreases in Vitro Beta-Lactam Susceptibility and Increases in Vivo Fitness of Streptococcus pyogenes.

Olsen, Randall J; Zhu, Luchang; Mangham, Regan E; Faili, Ahmad; Kayal, Samer; Beres, Stephen B; Musser, James M.

Afiliação

Olsen RJ; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas; Departments of Pathology and Laboratory Medicine and Microbi
Zhu L; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas; Departments of Pathology and Laboratory Medicine and Microbi
Mangham RE; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas.
Faili A; Inserm, CIC 1414, Rennes, France; Faculty of Pharmacy, Université Rennes 1, Rennes, France; CHU de Rennes, Rennes, France.
Kayal S; Inserm, CIC 1414, Rennes, France; CHU de Rennes, Rennes, France; Faculty of Medicine, Université Rennes 1, Rennes, France.
Beres SB; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas.
Musser JM; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas; Departments of Pathology and Laboratory Medicine and Microbi

Am J Pathol ; 192(10): 1397-1406, 2022 10.

Article em En | MEDLINE | ID: mdl-35843262

Assuntos

Fasciite Necrosante; Miosite; Animais; Antibacterianos/farmacologia; Camundongos; Penicilina G; Proteínas de Ligação às Penicilinas/genética; Penicilinas/farmacologia; Proteínas Recombinantes de Fusão; Streptococcus pneumoniae; Streptococcus pyogenes/genética; beta-Lactamas/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fasciite Necrosante / Miosite Limite: Animals Idioma: En Revista: Am J Pathol Ano de publicação: 2022 Tipo de documento: Article

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