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Assessment of the association of OCT3/4 with GLUT1 and CD105 in oral squamous cell carcinoma using dual immunohistochemistry.
Derakhshan, Samira; Mahdavi, Nazanin; Kardouni Khoozestani, Neda; Nasr Esfahani, Bita; Heidarian, Foroozan; Rahrotaban, Sedigheh; Abdolrahmani, Ali.
Afiliação
  • Derakhshan S; Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahdavi N; Cancer Preclinical Imaging Group, Preclinical Core Facility, Tehran University of Medical Sciences, Tehran, Iran.
  • Kardouni Khoozestani N; Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Nasr Esfahani B; Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Heidarian F; School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Rahrotaban S; School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Abdolrahmani A; Tehran University of Medical Sciences, Tehran, Iran.
BMC Oral Health ; 22(1): 300, 2022 07 19.
Article em En | MEDLINE | ID: mdl-35854304
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral and maxillofacial region. This study aimed to investigate the role of cancer stem cells (CSCs) in angiogenesis and hypoxic response in OSCC. METHODS: This retrospective observational study evaluated 56 cases of OSCC using dual immunohistochemistry. Octamer-binding transcription factor 3/4 (OCT3/4) marker was used to evaluate CSC activity. Glucose transporter 1 (GLUT1) marker was used to evaluate the hypoxic response and angiogenesis, while endoglin (CD105) was used to evaluate the late stage of angiogenesis and blood vessel formation. RESULTS: Co-expression of OCT3/4 and GLUT1 was noted in 11 of 12 patients with grade III OSCC. However, we did not observe co-expression of these markers in 13 of 22 patients with grade I OSCC. Although we observed a significant correlation between co-expression of GLUT1 and OCT3/4 and tumor grade, there was no significant correlation between co-expression of OCT3/4 and CD105 and different grades of OSCC. CONCLUSIONS: CSCs could play important roles in the initial stages of hypoxic response and angiogenesis. Our result reported that in higher grades of OSCC, GLUT1 as a first response to hypoxic situations might be a result of CSCs. Further studies are required to discover other biomarkers, their roles, and associated pathways of CSCs in OSCC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Oral Health Assunto da revista: ODONTOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irã

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Oral Health Assunto da revista: ODONTOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irã