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The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger, Sylvia; Hurdiss, Daniel L; Walser, Marcel; Malvezzi, Francesca; Mayor, Jennifer; Ryter, Sarah; Moreno, Hector; Liechti, Nicole; Bosshart, Andreas; Iss, Chloé; Calabro, Valérie; Cornelius, Andreas; Hospodarsch, Tanja; Neculcea, Alexandra; Looser, Thamar; Schlegel, Anja; Fontaine, Simon; Villemagne, Denis; Paladino, Maria; Schiegg, Dieter; Mangold, Susanne; Reichen, Christian; Radom, Filip; Kaufmann, Yvonne; Schaible, Doris; Schlegel, Iris; Zitt, Christof; Sigrist, Gabriel; Straumann, Marcel; Wolter, Julia; Comby, Marco; Sacarcelik, Feyza; Drulyte, Ieva; Lyoo, Heyrhyoung; Wang, Chunyan; Li, Wentao; Du, Wenjuan; Binz, H Kaspar; Herrup, Rachel; Lusvarghi, Sabrina; Neerukonda, Sabari Nath; Vassell, Russell; Wang, Wei; Adler, Julia M; Eschke, Kathrin; Nascimento, Mariana; Abdelgawad, Azza; Gruber, Achim D; Bushe, Judith; Kershaw, Olivia.
Afiliação
  • Rothenberger S; Spiez Laboratory, Austrasse, Spiez, Switzerland.
  • Hurdiss DL; Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
  • Walser M; Department Biomolecular Health Sciences, Division Infectious Diseases & Immunology - Virology section, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  • Malvezzi F; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, Netherlands.
  • Mayor J; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Ryter S; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Moreno H; Spiez Laboratory, Austrasse, Spiez, Switzerland.
  • Liechti N; Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
  • Bosshart A; Spiez Laboratory, Austrasse, Spiez, Switzerland.
  • Iss C; Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
  • Calabro V; Spiez Laboratory, Austrasse, Spiez, Switzerland.
  • Cornelius A; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Hospodarsch T; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Neculcea A; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Looser T; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Schlegel A; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Fontaine S; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Villemagne D; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Paladino M; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Schiegg D; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Mangold S; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Reichen C; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Radom F; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Kaufmann Y; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Schaible D; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Schlegel I; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Zitt C; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Sigrist G; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Straumann M; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Wolter J; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Comby M; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Sacarcelik F; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Drulyte I; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Lyoo H; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Wang C; Molecular Partners AG, Zurich-Schlieren, Switzerland.
  • Li W; Materials and Structural Analysis, Thermo Fisher Scientific, Eindhoven, Netherlands.
  • Du W; Department Biomolecular Health Sciences, Division Infectious Diseases & Immunology - Virology section, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  • Binz HK; Department Biomolecular Health Sciences, Division Infectious Diseases & Immunology - Virology section, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  • Herrup R; Department Biomolecular Health Sciences, Division Infectious Diseases & Immunology - Virology section, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  • Lusvarghi S; Department Biomolecular Health Sciences, Division Infectious Diseases & Immunology - Virology section, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  • Neerukonda SN; Binz Biotech Consulting, Zug, Switzerland.
  • Vassell R; Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Wang W; Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Adler JM; Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Eschke K; Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Nascimento M; Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Abdelgawad A; Freie Universität Berlin, Institut für Virologie, Berlin, Germany.
  • Gruber AD; Freie Universität Berlin, Institut für Virologie, Berlin, Germany.
  • Bushe J; Freie Universität Berlin, Institut für Virologie, Berlin, Germany.
  • Kershaw O; Freie Universität Berlin, Institut für Virologie, Berlin, Germany.
Nat Biotechnol ; 40(12): 1845-1854, 2022 12.
Article em En | MEDLINE | ID: mdl-35864170
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Nat Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Nat Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suíça