Mendelian randomization analysis identified causal Association of Childhood Obesity with adult major depressive disorder.
Pediatr Obes
; 17(12): e12960, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-35869568
ABSTRACT
BACKGROUND:
Childhood obesity is associated with adult major depressive disorder (MDD), but their causality is not clear.METHODS:
We performed a two-sample Mendelian randomization (MR) analysis to explore the causality of childhood body mass index (BMI) and childhood obesity on MDD, followed by a multivariable MR (MVMR) analysis to investigate the potential role of adult BMI in mediating such effect. We accessed genome-wide association summary statistics of childhood BMI, childhood obesity, adult BMI and adult MDD from the Early Growth Genetics consortium (nBMI = 47 541, nobesity = 24 160), the Genetic Investigation of Anthropometric Traits consortium (nadult_BMI = â¼700 000) and the Psychiatric Genomics consortium (nMDD = 500 199), respectively. The MR-PRESSO test was performed to remove SNPs with potential pleiotropic effect. The MR analysis was performed by inverse-variance weighted test. Further sensitivity analyses, including the MR-Egger intercept test and leave-one-out analysis, were performed to evaluate the reliability of the results.RESULTS:
Our study found that childhood obesity might increase the odds of developing MDD in adults (OR = 1.03, 95% CI 1.01-1.06, p = 2.6 × 10-3 ). Children with higher BMI were more likely to develop MDD in adulthood, with an OR of 1.12 per standard deviation score (SDS) increase in BMI (95% CI 1.07-1.17, p = 4.4 × 10-7 ). Sensitivity analyses verified the reliability of the causality between childhood BMI/obesity and MDD. Further MVMR results revealed that the impact of childhood BMI on MDD risk was predominantly mediated by adult BMI.CONCLUSION:
Our findings provided evidence of a causal relationship between childhood BMI/obesity and adult MDD, thus providing new insights into the prevention of MDD.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtorno Depressivo Maior
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Obesidade Infantil
Tipo de estudo:
Clinical_trials
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Child
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Humans
Idioma:
En
Revista:
Pediatr Obes
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China